2026年世界杯官网附属东方医院，微创介入治疗中心，副研究员，硕士生导师。聚焦肝癌类器官模型开发与应用，肝癌分子靶标挖掘，系统开展肝癌异质性和精准治疗策略研究，率先建立肝癌类器官模型并进行多维组学分析，提出靶向免疫逃逸的新型协同治疗策略，揭示染色质重塑检查点在肝细胞命运调控中的作用机制，完成多项非酒精性脂肪型肝炎药物研发和临床注册申报。相关研究工作发表在Nature、Cell、Cancer Cell, Science Translational Medicine、Cell Research、Cancer Discovery等杂志。获上海市东方英才（青年），浦东新区卫生优秀青年人才（A类），主持国自然面上和青年基金项目、上海市科委原创探索项目，以及博士后创新研究基金，参与多项国家省部级重点项目。
主持和主要参与项目：
1. 上海市科学技术委员会，上海市东方英才青年项目，类器官与多维组学驱动的肝癌精准治疗策略研究与临床转化，2026-01至2028-12，40万元
2. 国家自然科学基金委员会，面上项目，82473502，基于肿瘤类器官的磷酸化蛋白质组学揭示肝癌异质性并发掘创新药物靶标和个性化治疗策略，2025-01至2028-12，49万元，在研，主持
3. 上海市科学技术委员会，自然科学基金-原创探索项目，22ZR1479100，基于肝癌类器官的药物多组学研究及药物响应预测，2022-04至2025-03，50万元，结题，主持
4. 国家自然科学基金委员会，青年科学基金项目，31601186，诱导肝向转分化过程中表观遗传修饰抹除与重建的分子机制，2017-01-01至2019-12-31，20万元，结题，主持
5. 中国博士后科学基金委员会，面上资助项目，2020M681180，肝癌中DNA损伤响应通路的多组学分析及对免疫治疗和靶向药物敏感性的作用机制研究，2020-12至2023-06，8万，结题，主持
6. 国家自然科学基金委员会, 专项项目, 82341008, 2023-03-01 至 2026-02-28, 200万元, 参与
7. 国家自然科学基金委员会, 重点项目, 82130077, 2022-01-01 至 2026-12-31, 291万元, 参与
8.上海市科学技术委员会，科技创新行动计划，21JC1401200，类器官模拟胆道肿瘤发生发展的可塑性和异质性并解析机制的研究，2021-10至2024-09，300万元，结题，参与
代表性论文：
1. Shuyi Ji#, Li Feng#, Zile Fu#, Gaohua Wu#, Yingcheng Wu#, Youpei Lin, Dayun Lu, Peng Cui, Zijian Yang, Chen Sang, Guohe Song, Shangli Cai, Yuanchuang Li, Hanqing Lin, Shu Zhang, Xiaoying Wang, Shuangjian Qiu, Xiaoming Zhang, Guoqiang Hua, Junqiang Li, Jian Zhou, Zhi Dai, Xiangdong Wang, Li Ding, Pei Wang, Daming Gao, Bing Zhang, Henry Rodriguez, Jia Fan, Hans Clevers, Hu Zhou*, Yidi Sun*, Qiang Gao*, Pharmaco-proteogenomic characterization of liver cancer organoids for precision oncology. Science Translational Medicine. 2023 Jul 26;15(706):eadg3358. IF = 19.343
2. Wu Yang #, Siying Wang #, Shuyi Ji #, Jian Wang #, Shuo Lian, Zhe Li, Robin A Jansen, Wei Wu, Kongyan Niu, Zhen Sun, Qi Jia, Jiaojiao Zheng, Huijue Zhu, Xuan Deng, Liqin Wang, Zhoulong Fan, Yaoping Shi, Cor Lieftink, Ming Guan, Roderick L Beijersbergen, Wenxin Qin, Qiang Gao, René Bernards, Haojie Jin, CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma. Proc Natl Acad Sci USA. 2025 Sep 30;122(39):e2519568122. doi: 10.1073/pnas.2519568122. Epub 2025 Sep 24. IF = 9.1
3. Chen Yang#, Haigang Geng#, Xupeng Yang#, Shuyi Ji#, Zhicheng Liu#, Hao Feng#, Qian Li, Tangansu Zhang, Sisi Zhang, Xuhui Ma, Chuchen Zhu, Nuo Xu, Yuhan Xia, Yan Li, Hongye Wang, Chune Yu, Shangce Du, Beiping Miao, Lei Xu, Hui Wang, Ying Cao, Botai Li, Lili Zhu, Xiangyu Tang, Haoyu Zhang, Chunchao Zhu, Zhao Huang, Chao Leng, Haiyan Hu, Xiaoping Chen, Shengxian Yuan, Guangzhi Jin, René Bernards, Chong Sun*, Quan Zheng*, Wenxin Qin*, Qiang Gao*, Cun Wang*, Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy. Cancer Cell. 2024 Dec 9;42(12):2064-2081.e19. doi: 10.1016/j.ccell.2024.10.008. Epub 2024 Nov 7. IF = 48.8
4. Yingcheng Wu#, Jiaqiang Ma#, Xupeng Yang#, Fang Nan#, Tiancheng Zhang#, Shuyi Ji, Dongning Rao, Hua Feng, Ke Gao, Xixi Gu, Shan Jiang, Guohe Song, Jiaomeng Pan, Mao Zhang, Yanan Xu, Shu Zhang, Yihui Fan, Xiaoying Wang, Jian Zhou, Li Yang*, Jia Fan*, Xiaoming Zhang*, Qiang Gao*, Neutrophil profiling illuminates anti-tumor antigen-presenting potency, Cell. 2024, 187: 1-18. IF = 64.5
5. Shuyi Ji#, Linying Zhu#, Yimeng Gao, Xiaoran Zhang, Yupeng Yan, Jin Cen, Rongxia Li, Rong Zeng, Lujian Liao, Chunhui Hou, Yawei Gao, Shaorong Gao, Gang Wei*, Lijian Hui*, Baf60b-mediated ATM-p53 activation blocks cell identity conversion by sensing chromatin opening, Cell Research. 2017, 27(5): 642-656. IF = 28.1
6. Shuyi Ji, Ludi Zhang, Lijian Hui*, Cell fate conversion: direct induction of hepatocyte-like cells from fibroblasts, Journal of Cellular Biochemistry. 2013, 114(2): 256-265. Review, IF = 4.481
7. Xinpei Yi, Bo Wen, Shuyi Ji, Alex Saltzman, Eric J Jaehnig, Jonathan T Lei, Qiang Gao, Bing Zhang, Deep learning prediction boosts phosphoproteomics-based discoveries through improved phosphopeptide identification, Mol Cell Proteomics. 2024 Feb;23(2):100707. IF = 6.3
8. Pengyu Huang, Zhiying He, Shuyi Ji, Huawang Sun, Dao Xiang, Changcheng Liu, Yiping Hu, Xin Wang, Lijian Hui*, Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors, Nature. 2011, 475(7356): 386-389. IF = 69.504
9. Mao Zhang#, Yingying Huang#, Jiaomeng Pan#, Chen Sang#, Youpein Lin, Liangqing Dong, Xia Shen, Yingcheng Wu, Guohe Song, Shuyi Ji, Fen Liu, Mengcheng Wang, Yuyan Zheng, Sirui Zhang, Zefeng Wang, Jianke Ren, Daming Gao, Jian Zhou, Jia Fam, Wu Wei*, Jian Lin*, Qiang Gao*, An inflammatory checkpoint generated by IL1RN splicing offers therapeutic opportunity for KRAS mutant intrahepatic cholangiocarcinoma, Cancer Discovery. 2023 Jul 24;CD-23-0282. IF = 28.2
10. Guohe Song#, Yang Shi#, Lu Meng#, Jiaqiang Ma#, Siyuan Huang, Juan Zhang, Yingcheng Wu, Jiaxin Li, Youpei Lin, Shuaixi Yang, Dongning Rao, Yifei Cheng, Jian Lin, Shuyi Ji, Yuming Liu, Shan Jiang, Xiaoliang Wang, Shu Zhang, Aiwu Ke, Xiaoying Wang, Ya Cao, Yuan Ji, Jian Zhou, Jia Fan, Xiaoming Zhang*, Ruibin Xi*, Qiang Gao*, Single-cell transcriptomic analysis suggests two molecularly subtypes of intrahepatic cholangiocarcinoma, Nature Communication. 2022 Mar 28;13(1):1642
